SCHEMBL21372010

SCHEMBL21372010

O=C1CCc2c(Cl)nc(I)nc2N1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.34
SRC P12931 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13424558 0.79 MEN1 (0.42) CRBNSRC
SCHEMBL21372009 0.79 SRC (0.40) CRBNSRC
SCHEMBL2820233 0.76 CRBN (0.32) CRBN
SCHEMBL14020856 0.75 CRBN (0.31) CRBN
SCHEMBL2821501 0.72
SCHEMBL1531608 0.69 AKT1 (0.37) CRBN
SCHEMBL2819706 0.67 MAPT (0.36)
SCHEMBL17926499 0.64 SRC (0.43) SRC
SCHEMBL4764114 0.63 SRC (0.42) CRBNSRC
Succinimide SCHEMBL3805994 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3639824-A1 TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION GlaxoSmithKline Intellectual Property Development Limited (GB) 2020-04-22 EP disclosed
EP-3182973-B1 TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION GLAXOSMITHKLINE IP DEV LTD (GB) 2019-09-18 EP disclosed