Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21371766 | 0.89 | JAK2 (0.42) | JAK2JAK3JAK1TYK2USP2 | |
| SCHEMBL2326147 | 0.78 | JAK2 (0.36) | JAK2JAK3JAK1TYK2PIK3CD | |
| SCHEMBL21564774 | 0.74 | USP2 (0.50) | JAK2JAK3JAK1TYK2USP2 | |
| SCHEMBL27282469 | 0.72 | PIK3CD (0.42) | PIK3CDMEN1NPC1RAB9AKMT2A | |
| SCHEMBL15308457 | 0.72 | PIK3CD (0.42) | PIK3CDMEN1NPC1RAB9AKMT2A | |
| SCHEMBL2625903 | 0.71 | PIK3CD (0.43) | PIK3CDMEN1NPC1RAB9AKMT2A | |
| SCHEMBL12326039 | 0.71 | — | — | |
| SCHEMBL3957140 | 0.70 | NPC1 (0.33) | JAK2JAK3JAK1TYK2PIK3CD | |
| SCHEMBL16264298 | 0.69 | DRD3 (0.38) | PIK3CD | |
| SCHEMBL3436789 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180344-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE | PFIZER (US) | 2019-09-18 | — | — | EP | disclosed |