Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13299225 | 1.00 | TOP2A (0.40) | TOP2AKCNH2PDE3BPDE3A | |
| SCHEMBL3362817 | 0.91 | TOP2A (0.40) | TOP2AKCNH2PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL3366759 | 0.90 | TOP2A (0.40) | TOP2AKCNH2PDE3BPDE3A | |
| SCHEMBL21372026 | 0.88 | TOP2A (0.41) | TOP2A | |
| SCHEMBL3363740 | 0.88 | TOP2A (0.41) | TOP2A | |
| SCHEMBL21371943 | 0.85 | TOP2A (0.45) | TOP2AKCNH2 | |
| SCHEMBL3324251 | 0.85 | TOP2A (0.45) | TOP2AKCNH2 | |
| SCHEMBL13114364 | 0.84 | TOP2A (0.43) | TOP2AKCNH2 | |
| Hydrochloric Acid SCHEMBL3329007 | 0.84 | TOP2A (0.44) | TOP2AKCNH2 | |
| SCHEMBL3331529 | 0.81 | TOP2A (0.40) | TOP2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3639824-A1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-04-22 | — | — | EP | disclosed |
| EP-3182973-B1 | TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-09-18 | — | — | EP | disclosed |