Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 4/20 | 0.33 |
| ▸ | PBK | Q96KB5 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21372715 | 0.84 | IDO1 (0.46) | IDO1CYP3A4CYP3A5PBKTDO2 | |
| SCHEMBL21372902 | 0.84 | IDO1 (0.46) | IDO1CYP3A4CYP3A5LMNATDO2 | |
| SCHEMBL21372683 | 0.83 | IDO1 (0.46) | IDO1LMNA | |
| SCHEMBL21372871 | 0.80 | IDO1 (0.47) | IDO1CYP3A4BRD4 | |
| SCHEMBL21372956 | 0.80 | IDO1 (0.47) | IDO1CYP3A4CYP3A5LMNASMN1; SMN2 | |
| SCHEMBL21373039 | 0.79 | IDO1 (0.41) | IDO1PBKBRD4TDO2 | |
| SCHEMBL18236823 | 0.78 | CYP3A4 (0.44) | CYP3A4CYP3A5 | |
| SCHEMBL18224891 | 0.78 | CYP3A4 (0.44) | CYP3A4CYP3A5 | |
| SCHEMBL18224890 | 0.78 | CYP3A4 (0.44) | CYP3A4CYP3A5 | |
| SCHEMBL21373044 | 0.78 | MKNK1 (0.39) | IDO1CYP3A4CYP3A5PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | claimed |