Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 18/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 13/20 | 0.57 |
| ▸ | BAK1 | Q16611 | 7/20 | 0.56 |
| ▸ | MDM4 | O15151 | 1/20 | 0.52 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | BID | P55957 | 1/20 | 0.52 |
| ▸ | BAX | Q07812 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.52 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.52 |
| ▸ | BAD | Q92934 | 1/20 | 0.52 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21896468 | 0.85 | BCL2L1 (0.59) | BCL2BCL2L1BAK1MDM4BCL2L11 | |
| SCHEMBL23776365 | 0.80 | BCL2L1 (0.81) | BCL2BCL2L1BAK1MDM4BCL2L11 | |
| SCHEMBL16551613 | 0.77 | BCL2 (0.49) | BCL2BCL2L1BAK1 | |
| SCHEMBL2388437 | 0.77 | BCL2 (0.71) | BCL2BCL2L1BAK1MDM4BCL2L11 | |
| SCHEMBL2994558 | 0.76 | BCL2 (0.71) | BCL2BCL2L1BAK1 | |
| SCHEMBL19308887 | 0.75 | BCL2 (0.78) | BCL2BCL2L1BAK1 | |
| SCHEMBL1744739 | 0.75 | BCL2 (0.67) | BCL2BCL2L1BAK1MDM4BCL2L11 | |
| SCHEMBL19365213 | 0.74 | BCL2 (0.70) | BCL2BCL2L1BAK1 | |
| SCHEMBL19424330 | 0.74 | BCL2 (0.72) | BCL2BCL2L1BAK1 | |
| SCHEMBL20778266 | 0.74 | BCL2 (0.70) | BCL2BCL2L1BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220425-A1 | BCL-XL/BCL-2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2019178528-A1 | NANOPARTICLE COMPOSITIONS | JANUARY THERAPEUTICS, INC. (US) | 2019-09-19 | — | — | WO | disclosed |