Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.71 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | BLK | P51451 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | CTSC | P53634 | 1/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.61 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.61 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.61 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10127890 | 0.85 | EGFR (0.80) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL4164770 | 0.83 | EGFR (1.00) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL9945445 | 0.83 | EGFR (0.86) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL21375546 | 0.82 | EGFR (0.58) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL2723295 | 0.81 | EGFR (1.00) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL9945454 | 0.81 | EGFR (0.87) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL2730287 | 0.81 | EGFR (1.00) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL10128079 | 0.80 | EGFR (0.73) | EGFRPLK4GAKNUAK1JAK2 | |
| SCHEMBL17059712 | 0.80 | EGFR (1.00) | EGFR | |
| SCHEMBL21375235 | 0.79 | EGFR (0.80) | EGFRPLK4GAKNUAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177374-A1 | 2, 4, 5-SUBSTITUTED PYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER OR INFLAMMATORY DISEASE | 포로노이바이오 주식회사 | 2019-09-19 | — | — | WO | disclosed |