Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HINT1 | P49773 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19146388 | 1.00 | KDM4E (0.49) | KDM4ETAS1R3TAS1R1ALDH1A1LMNA | |
| SCHEMBL24197308 | 1.00 | KDM4E (0.49) | KDM4ETAS1R3TAS1R1ALDH1A1LMNA | |
| SCHEMBL26049120 | 0.90 | KDM4E (0.47) | KDM4ETAS1R3TAS1R1ALDH1A1LMNA | |
| SCHEMBL26152399 | 0.89 | KDM4E (0.48) | KDM4ETAS1R3TAS1R1ALDH1A1POLA1 | |
| SCHEMBL19146416 | 0.88 | KDM4E (0.47) | KDM4ETAS1R3TAS1R1POLA1 | |
| SCHEMBL20833440 | 0.87 | KDM4E (0.49) | KDM4ETAS1R3TAS1R1ALDH1A1POLA1 | |
| SCHEMBL20833132 | 0.86 | KDM4E (0.48) | KDM4ETAS1R3TAS1R1ALDH1A1POLA1 | |
| SCHEMBL24102841 | 0.84 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1ALDH1A1POLA1 | |
| SCHEMBL23898886 | 0.84 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1ALDH1A1POLA1 | |
| SCHEMBL21171850 | 0.84 | KDM4E (0.46) | KDM4ETAS1R3TAS1R1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922637-A1 | MODIFIED OLIGONUCLEOTIDES FOR USE IN TREATMENT OF TAUOPATHIES | Janssen Pharmaceutica NV (BE) | 2021-12-15 | — | — | EP | disclosed |
| WO-2019175260-A2 | MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE IN TAUOPATHIES | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-19 | — | — | WO | disclosed |