Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 1.00 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.69 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.69 |
| ▸ | BRD2 | P25440 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.61 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20291038 | 1.00 | BRD4 (1.00) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL21397757 | 1.00 | BRD4 (1.00) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL21397807 | 0.93 | BRD4 (0.86) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL21397837 | 0.92 | BRD4 (0.85) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL23787095 | 0.89 | BRD4 (0.80) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL20291400 | 0.89 | BRD4 (0.80) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL21397808 | 0.89 | BRD4 (0.80) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL20271590 | 0.88 | BRD4 (0.78) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL21378115 | 0.88 | BRD4 (0.78) | BRD4HCRTR1HCRTR2BRD2POLB | |
| SCHEMBL21397838 | 0.87 | BRD4 (0.76) | BRD4HCRTR1HCRTR2BRD2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975059-B2 | Small molecule BRD4 modulators for HIV epigenetic regulation | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-13 | — | — | US | disclosed |
| US-10975059-B2 | Small molecule BRD4 modulators for HIV epigenetic regulation | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190292168-A1 | NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-26 | — | — | US | disclosed |
| US-20190292168-A1 | NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975059-B2 | Small molecule BRD4 modulators for HIV epigenetic regulation | BRD4, BICRA, BRD3 | BRD4 1/4885HCRTR1 2820/4885HCRTR2 2899/4885 |
| US-20190292168-A1 | NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION | BRD4, BICRA, BRD3 | BRD4 1/4885HCRTR1 2810/4885HCRTR2 2933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.