Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.67 |
| ▸ | PRMT5 | O14744 | 18/20 | 0.59 |
| ▸ | WDR77 | Q9BQA1 | 18/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21384872 | 1.00 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL17578645 | 0.82 | CARM1 (0.63) | CARM1PRMT5WDR77 | |
| SCHEMBL15825243 | 0.82 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL15823999 | 0.82 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL29374314 | 0.82 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL15824119 | 0.82 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL29373636 | 0.82 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL29373628 | 0.82 | CARM1 (0.67) | CARM1PRMT5WDR77 | |
| SCHEMBL30019323 | 0.81 | CARM1 (0.74) | CARM1PRMT5WDR77 | |
| SCHEMBL19286466 | 0.81 | CARM1 (1.00) | CARM1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768670-A1 | IMIDAZOLIDIN-2-ONE COMPOUNDS AS PRMT5 MODULATORS | Aurigene Discovery Technologies Limited (IN) | 2021-01-27 | — | — | EP | disclosed |
| CN-112105609-A | Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors | 奥瑞基尼探索技术有限公司 | 2020-12-18 | — | — | CN | disclosed |
| WO-2019180628-A1 | IMIDAZOLIDIN-2-ONE COMPOUNDS AS PRMT5 MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2019-09-26 | — | — | WO | disclosed |