Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 6/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756559 | 0.92 | FGFR1 (0.50) | FGFR1FGFR4 | |
| SCHEMBL21386604 | 0.84 | FGFR4 (0.37) | FGFR1FGFR4 | |
| SCHEMBL21386670 | 0.81 | FGFR4 (0.47) | FGFR1FGFR4 | |
| SCHEMBL21386669 | 0.79 | FGFR1 (0.51) | FGFR1FGFR4 | |
| SCHEMBL21756558 | 0.78 | FGFR1 (0.39) | FGFR1FGFR4SRC | |
| SCHEMBL21756598 | 0.78 | FGFR1 (0.48) | EGFRFGFR1FGFR4SRC | |
| SCHEMBL21386685 | 0.76 | FGFR4 (0.68) | EGFRFGFR1FGFR4 | |
| SCHEMBL21756524 | 0.76 | FGFR4 (0.68) | FGFR1FGFR4 | |
| SCHEMBL21756508 | 0.75 | FGFR4 (0.55) | FGFR1FGFR4 | |
| SCHEMBL18131810 | 0.71 | FGFR1 (0.70) | FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |