Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 8/20 | 0.51 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6802920 | 0.90 | HDAC8 (0.69) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL6802912 | 0.90 | HDAC8 (0.69) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL3006406 | 0.90 | HDAC8 (0.63) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL3006410 | 0.90 | HDAC8 (0.63) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL18474862 | 0.89 | HDAC8 (0.55) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL18444069 | 0.89 | HDAC8 (0.57) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL18444068 | 0.89 | HDAC8 (0.57) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL18474863 | 0.89 | HDAC8 (0.55) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL28218600 | 0.85 | HDAC8 (0.52) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL28218601 | 0.85 | HDAC8 (0.52) | HDAC8CTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331872-B1 | NOVEL SUBSTITUTED GLYCINE DERIVED FXIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-09-25 | — | — | EP | disclosed |