SCHEMBL21387355

SCHEMBL21387355

Cc1ccc(-c2noc(C3CN(S(=O)(=O)C4CCN(C)CC4)C3)n2)cc1NC(=O)c1cnc2ccccn12

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21372433 0.93 KIT (0.73) KIT
SCHEMBL14739815 0.92 KIT (0.76) KIT
SCHEMBL21372468 0.91 KIT (0.72) KIT
SCHEMBL21387471 0.90 KIT (0.89) KIT
SCHEMBL14740141 0.90 KIT (0.74) KIT
SCHEMBL14739331 0.90 KIT (0.68) KIT
SCHEMBL14740473 0.89 KIT (0.81) KIT
SCHEMBL14739445 0.89 KIT (0.81) KIT
SCHEMBL21387368 0.89 KIT (0.86) KIT
SCHEMBL14739907 0.88 KIT (0.79) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed