SCHEMBL21387397

SCHEMBL21387397

CC(=O)N1CC(c2nc(-c3ccc(F)c(NC(=O)c4cnc5ccccn45)c3)no2)C1

nearest known ligand 0.82

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14740220 0.93 KIT (0.81) KIT
SCHEMBL14740324 0.93 KIT (0.83) KIT
SCHEMBL21387416 0.92 KIT (0.82) KIT
SCHEMBL14739458 0.91 KIT (0.83) KIT
SCHEMBL14738951 0.90 KIT (1.00) KIT
SCHEMBL14739752 0.90 KIT (0.75) KIT
SCHEMBL14740077 0.89 KIT (0.77) KIT
SCHEMBL21387441 0.88 KIT (0.76) KIT
SCHEMBL14739802 0.88 KIT (0.76) KIT
SCHEMBL14739016 0.88 KIT (1.00) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed