SCHEMBL21387430

SCHEMBL21387430

Cc1ccc(-c2noc(CC3CN(C)C3)n2)cc1NC(=O)c1cnc2ccccn12

nearest known ligand 0.87

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14738446 0.93 KIT (1.00) KIT
SCHEMBL14740033 0.92 KIT (0.84) KIT
SCHEMBL21387408 0.92 KIT (0.84) KIT
SCHEMBL14739187 0.92 KIT (0.83) KIT
SCHEMBL27335883 0.91 KIT (0.94) KIT
SCHEMBL27337438 0.91 KIT (0.88) KIT
SCHEMBL14738642 0.91 KIT (0.82) KIT
SCHEMBL14739469 0.91 KIT (0.87) KIT
SCHEMBL14740274 0.90 KIT (0.91) KIT
SCHEMBL14753280 0.89 KIT (0.90) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed