SCHEMBL21387503

SCHEMBL21387503

Cc1ccc(-c2noc(C3CN(C)CCO3)n2)cc1NC(=O)c1cnc2ccccn12

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14738868 0.91 KIT (0.69) KIT
SCHEMBL14740363 0.91 KIT (0.69) KIT
SCHEMBL14739476 0.91 KIT (0.71) KIT
SCHEMBL14739808 0.91 KIT (0.71) KIT
SCHEMBL14739053 0.91 KIT (0.71) KIT
SCHEMBL14758973 0.91 KIT (0.71) KIT
SCHEMBL14739307 0.91 KIT (0.71) KIT
SCHEMBL14739305 0.91 KIT (0.83) KIT
SCHEMBL14740015 0.90 KIT (0.70) KIT
SCHEMBL14753125 0.90 KIT (0.70) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed