Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.62 |
| ▸ | BRD2 | P25440 | 2/20 | 0.62 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.62 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TPH2 | Q8IWU9 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389545 | 0.85 | BRD4 (0.62) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL21389579 | 0.84 | MEN1 (0.66) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL16028820 | 0.84 | ATM (0.71) | BRDTMEN1KMT2AATMAPOBEC3G | |
| SCHEMBL21389578 | 0.83 | MEN1 (0.83) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL22105566 | 0.83 | BRD4 (0.59) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL22105408 | 0.77 | BRD4 (0.52) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL19090445 | 0.77 | BRD4 (1.00) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL22105477 | 0.76 | MEN1 (0.68) | BRD4MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL22105779 | 0.76 | BRD4 (0.53) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL19066324 | 0.76 | BRD4 (0.62) | BRD4BRD2BRD3BRDTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-01-18 | — | — | US | disclosed |
| EP-3397640-B1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INST NAT SANTE RECH MED (FR) | 2021-08-04 | — | — | EP | disclosed |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | BET1, BRD4, BRD3 | BRD4 2/4885BRD2 6/4885BRD3 3/4885 |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | BET1, BRD4, BRD3 | BRD4 2/4885BRD2 6/4885BRD3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.