⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277052 | 0.73 | — | — | |
| SCHEMBL2141813 | 0.67 | — | — | |
| SCHEMBL3130453 | 0.67 | — | — | |
| SCHEMBL10952924 | 0.63 | — | — | |
| SCHEMBL596895 | 0.63 | — | — | |
| SCHEMBL1599923 | 0.60 | — | — | |
| SCHEMBL2219404 | 0.60 | — | — | |
| SCHEMBL2139246 | 0.60 | — | — | |
| SCHEMBL11109726 | 0.58 | — | — | |
| SCHEMBL1199564 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993604-B2 | Substituted pyrazolo[4,3-H]quinazolines as protein kinase inhibitors | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2024-05-28 | — | — | US | disclosed |
| EP-4367107-A1 | NOVEL COMPOUNDS AS INHIBITORS OF PCSK9 | Shengke Pharmaceuticals (Jiangsu) Ltd. (CN) | 2024-05-15 | — | — | EP | disclosed |
| CN-117616019-A | Novel compounds as PCSK9 inhibitors | 晟科药业（江苏）有限公司 | 2024-02-27 | — | — | CN | disclosed |
| US-20230122967-A1 | NOVEL COMPOUNDS AS INHIBITORS OF PCSK9 | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| WO-2023280155-A1 | NOVEL COMPOUNDS AS INHIBITORS OF PCSK9 | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2023-01-12 | — | — | WO | disclosed |
| US-20220227775-A1 | 1H-PYRAZOLO[4,3-H]QUINAZOLINE COMPOUND SERVING AS PROTEIN KINASE INHIBITOR | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2022-07-21 | — | — | US | disclosed |
| US-20220218732-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2022-07-14 | — | — | US | disclosed |
| CN-111094291-B | 1H-pyrazolo [4,3-H ] quinazoline compound as protein kinase inhibitor | 晟科药业（江苏）有限公司 | 2022-06-21 | — | — | CN | disclosed |
| EP-3666774-B1 | 1H-PYRAZOLO[4,3-H]QUINAZOLINE COMPOUND SERVING AS PROTEIN KINASE INHIBITOR | SHENGKE PHARMACEUTICALS JIANGSU LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| US-11319323-B2 | Substituted pyrazolo[4,3-H]quinazolines as protein kinase inhibitors | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2022-05-03 | — | — | US | disclosed |
| US-20020103211-A1 | TRICYCLIC FUSED XANTHINE COMPOUNDS AND THEIR USES | CELL THERAPEUTICS, INC. | 2002-08-01 | — | — | US | disclosed |
| US-20020028823-A1 | THERAPEUTIC COMPOUNDS FOR INHIBITING INTERLEUKIN-12 SIGNALING AND METHODS FOR USING SAME | CELL THERAPEUTICS, INC. | 2002-03-07 | — | — | US | disclosed |
| EP-1171442-A1 | XANTHINE DERIVATIVES AND ANALOGS AS CELL SIGNALLING INHIBITORS | CELL THERAPEUTICS, INC. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061583-A1 | XANTHINE DERIVATIVES AND ANALOGS AS CELL SIGNALING INHIBITORS | CELL THERAPEUTICS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
| US-5824677-A | SUBSTITUTED WITH HETEROCYCLIC RING, ANTIINFLAMMATORY, IMMUNOSUPPRESSIVE | CELL THERAPEUTICS, INC. (US) | 1998-10-20 | — | — | US | disclosed |
| US-5777117-A | ANTIINFLAMMATORY, IMMUNOSUPPRESSIVE, CYTOTOXIC AGENTS; MICROBIOCIDES, FUNGICIDES | CELL THERAPEUTICS, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5750575-A | ANTIINFLAMMATORY AGENTS; IMMUNOSUPPRESSANTS; CYTOTOXIC AGENTS; MICROBIOCIDES; FUNGICIDES | CELL THERAPEUTICS, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5670507-A | Method for reversing multiple drug resistant phenotype | CELL THERAPEUTICS, INC. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5641783-A | ANTIINFLAMMATORY OR IMMUNOSUPPRESSIVE AGENTS | CELL THERAPEUTICS, INC. (US) | 1997-06-24 | — | — | US | disclosed |
| WO-1995013808-A1 | METHOD FOR SELECTIVELY INHIBITING IL-2 SIGNAL TRANSDUCTION | CELL THERAPEUTICS, INC. (US) | 1995-05-26 | — | — | WO | disclosed |