Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 19/20 | 0.79 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22924907 | 0.88 | CTPS1 (1.00) | CTPS1 | |
| SCHEMBL30416376 | 0.85 | CTPS1 (0.77) | CTPS1 | |
| SCHEMBL22924964 | 0.85 | CTPS1 (0.77) | CTPS1 | |
| SCHEMBL21381595 | 0.84 | CTPS1 (1.00) | CTPS1 | |
| SCHEMBL26977288 | 0.81 | CTPS1 (0.64) | CTPS1 | |
| SCHEMBL22924887 | 0.81 | CTPS1 (0.69) | CTPS1 | |
| SCHEMBL22924906 | 0.79 | CTPS1 (0.82) | CTPS1 | |
| SCHEMBL21373804 | 0.75 | CTPS1 (1.00) | CTPS1 | |
| SCHEMBL21392120 | 0.74 | CTPS1 (0.81) | CTPS1 | |
| SCHEMBL23121287 | 0.71 | CTPS1 (0.57) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |