⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL5012111 | 0.88 | GLA (0.46) | — | |
| SCHEMBL5254160 | 0.85 | GLA (0.44) | — | |
| SCHEMBL8616571 | 0.82 | KMT2A (0.50) | — | |
| SCHEMBL5009914 | 0.81 | GLA (0.44) | — | |
| SCHEMBL8613762 | 0.80 | — | — | |
| SCHEMBL12230949 | 0.80 | — | — | |
| SCHEMBL4394905 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL19119174 | 0.78 | MAPT (0.47) | — | |
| SCHEMBL23366886 | 0.78 | MAPT (0.44) | — | |
| SCHEMBL17712787 | 0.78 | MAPT (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721015-B1 | PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP ASSETS BV (NL) | 2017-03-01 | — | — | EP | claimed |
| EP-2841424-A1 | PROCESS FOR SYNTHESIS OF 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP Assets B.V. (NL) | 2015-03-04 | — | — | EP | claimed |
| US-8916715-B2 | Process for 4-methyloxazole-5-carboxamide | DSM IP ASSETS B.V. (NL) | 2014-12-23 | — | — | US | claimed |
| US-20140206880-A1 | PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP ASSETS B.V. (NL) | 2014-07-24 | — | — | US | claimed |
| EP-2721015-A1 | PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP Assets B.V. (NL) | 2014-04-23 | — | — | EP | claimed |
| WO-2013160322-A1 | PROCESS FOR SYNTHESIS OF 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP ASSETS B.V. (NL) | 2013-10-31 | — | — | WO | claimed |
| WO-2012175304-A1 | PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP ASSETS B.V. (NL) | 2012-12-27 | — | — | WO | claimed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | claimed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | claimed |
| EP-0775691-B1 | Process for the preparation of nitriles | HOFFMANN LA ROCHE (CH) | 2000-01-26 | — | — | EP | claimed |
| US-5817827-A | SULFUR TRIOXIDE-AMINE ADDUCT CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1998-10-06 | — | — | US | claimed |
| EP-0775691-A1 | Process for the preparation of nitriles | F. HOFFMANN-LA ROCHE AG (CH) | 1997-05-28 | — | — | EP | claimed |
| EP-0492233-B1 | Method for the preparation of 5-cyano-4-alkyl-oxazol | HOFFMANN LA ROCHE (CH) | 1996-08-21 | — | — | EP | claimed |
| US-5502212-A | Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles | HOFFMANN-LA ROCHE INC. (US) | 1996-03-26 | — | — | US | claimed |
| US-4255584-A | REACTING 5-CARBAMOYL-4-METHYL OXAZOLE WITH ALKANE ANHYDRIDE IN THE PRESENCE OF A COPPER OR NICKEL CATALYST | HOFFMAN-LA ROCHE INC. (US) | 1981-03-10 | — | — | US | claimed |
| JP-9165383-A | — | — | None | — | — | JP | disclosed |
| JP-4321672-A | — | — | None | — | — | JP | disclosed |
| US-4093654-A | Production of pyridoxine intermediates from diketene | HOFFMANN-LA ROCHE INC. (US) | 1978-06-06 | — | — | US | disclosed |
| US-4026901-A | CATALYTIC DEHYDRATION; MOLECULAR SIEVE, SILICA, ALUMINA, OR PHOSPHORUS PENTOXIDE AS CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-4011234-A | N-ALKANOYL OXAZOLE-CARBOXAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1977-03-08 | — | — | US | disclosed |