⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23302207 | 0.74 | CCR4 (0.39) | — | |
| SCHEMBL24616408 | 0.73 | — | — | |
| SCHEMBL21393940 | 0.70 | — | — | |
| SCHEMBL21393954 | 0.70 | — | — | |
| SCHEMBL25269473 | 0.69 | SCD (0.37) | — | |
| SCHEMBL25220019 | 0.67 | PDE9A (0.39) | — | |
| SCHEMBL21393707 | 0.67 | NPC1 (0.30) | — | |
| SCHEMBL22753166 | 0.67 | HTR2A (0.33) | — | |
| SCHEMBL25216926 | 0.65 | KCNH2 (0.31) | — | |
| SCHEMBL21216395 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3578560-B1 | QUINAZOLINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2021-11-10 | — | — | EP | disclosed |
| US-10774082-B2 | Quinazoline compound | ASTELLAS PHARMA INC. (JP) | 2020-09-15 | — | — | US | disclosed |
| US-20200140437-A1 | QUINAZOLINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2020-05-07 | — | — | US | disclosed |
| US-10556906-B2 | Quinazoline compound | ASTELLAS PHARMA INC. (JP) | 2020-02-11 | — | — | US | disclosed |
| US-20190292182-A1 | QUINAZOLINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-09-26 | — | — | US | disclosed |