Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21388797 | 0.81 | MEN1 (0.45) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL21380747 | 0.77 | MEN1 (0.44) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL26155922 | 0.75 | PNP (0.48) | MEN1KMT2AHPGDADORA1KDM4E | |
| SCHEMBL18984687 | 0.74 | PNP (0.51) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| Hydrochloric Acid SCHEMBL8846302 | 0.73 | PNP (0.50) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL6100817 | 0.71 | MEN1 (0.47) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL10309248 | 0.71 | MEN1 (0.65) | MEN1KMT2AADORA1SMN1; SMN2MAPK1 | |
| SCHEMBL877790 | 0.69 | MEN1 (0.45) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL9408132 | 0.68 | MEN1 (0.51) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL13217689 | 0.68 | PIM1 (0.44) | MEN1KMT2AADORA1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10561655-B2 | SHP2 inhibitors and uses thereof | SYNBLIA THERAPEUTICS, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190290649-A1 | SHP2 INHIBITORS AND USES THEREOF | Suzhou Puhe BioPharma Co., Ltd. (CN) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290649-A1 | SHP2 INHIBITORS AND USES THEREOF | PTPN1, PTPN7, PTPN18 | MEN1 2793/4885KMT2A 2029/4885CYP1A2 4430/4885 |
| US-10561655-B2 | SHP2 inhibitors and uses thereof | PTPN1, PTPN7, PTPN18 | MEN1 2793/4885KMT2A 2029/4885CYP1A2 4430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.