Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 5/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAC1 | P63000 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502127 | 1.00 | CCR4 (0.42) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT | |
| SCHEMBL14569087 | 1.00 | CCR4 (0.42) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT | |
| SCHEMBL5501587 | 0.85 | CCR4 (0.42) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT | |
| SCHEMBL21402145 | 0.83 | CCR4 (0.43) | CCR4SLC2A1CACNA2D1MAPTRAC1 | |
| SCHEMBL14569086 | 0.83 | CCR4 (0.43) | CCR4SLC2A1CACNA2D1MAPTRAC1 | |
| SCHEMBL5503974 | 0.83 | CCR4 (0.43) | CCR4SLC2A1CACNA2D1MAPTRAC1 | |
| SCHEMBL5503962 | 0.82 | CCR4 (0.42) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT | |
| SCHEMBL14569085 | 0.82 | CCR4 (0.42) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT | |
| SCHEMBL5502290 | 0.82 | CCR4 (0.42) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT | |
| SCHEMBL5498963 | 0.81 | BRAF (0.46) | CCR4SLC2A1RPS6KB1CACNA2D1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | claimed |