Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.55 |
| ▸ | CCND1 | P24385 | 10/20 | 0.55 |
| ▸ | CCND3 | P30281 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.51 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.51 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.51 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.51 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCND2 | P30279 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29574744 | 0.92 | CDK4 (0.55) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL20203470 | 0.92 | CDK4 (0.55) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL21402870 | 0.91 | CDK4 (0.55) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL21402797 | 0.90 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL28754847 | 0.90 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL29575302 | 0.90 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL29574826 | 0.90 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL20203545 | 0.89 | CDK4 (0.61) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL29575585 | 0.84 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CDK6 | |
| SCHEMBL21402843 | 0.82 | CDK4 (0.51) | CDK4CCND1CCND3CDK2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036012-B | Pyrido [3,4-d ] pyrimidine derivatives and pharmaceutically acceptable salts thereof | 帝人制药株式会社 | 2022-05-10 | — | — | CN | claimed |
| EP-3546458-B1 | ((PYRIDIN-2-YL)-AMINO)PYRIDO[3,4-D]PYRIMIDINE AND ((PYRIDAZIN-3-YL)-AMINO)PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES AS CDK4/6 INHIBITORS FOR TREATING E.G. RHEUMATOID ARTHRITIS, ARTERIOSCLEROSIS, PULMONARY FIBROSIS, CEREBRAL INFARCTION OR CANCER | TEIJIN PHARMA LTD (JP) | 2021-01-06 | — | — | EP | claimed |
| CN-110036012-B | Pyrido [3,4-d ] pyrimidine derivatives and pharmaceutically acceptable salts thereof | 帝人制药株式会社 | 2022-05-10 | — | — | CN | disclosed |
| EP-3546458-A1 | PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2019-10-02 | — | — | EP | disclosed |