SCHEMBL21408355

SCHEMBL21408355

[2H]C([2H])([2H])n1c(C)c(C(=O)Nc2ccc(F)c(C#N)c2)c(C)c1C(=O)C(=O)NC(C)C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC10A1 Q14973 17/20 0.47
GRM4 Q14833 1/20 0.39
LRRK2 Q5S007 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30361242 1.00 SLC10A1 (0.47) SLC10A1GRM4LRRK2
SCHEMBL30361236 0.94 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL31659293 0.94 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL21408543 0.94 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL21427896 0.94 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL21408544 0.94 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL28492819 0.89 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL22906130 0.89 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL21428046 0.89 SLC10A1 (0.49) SLC10A1GRM4LRRK2
SCHEMBL30361258 0.89 SLC10A1 (0.49) SLC10A1GRM4LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019185016-A1 N-HETEROCYCLIC FIVE-MEMBERED RING-CONTAINING CAPSID PROTEIN ASSEMBLY INHIBITOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 正大天晴药业集团股份有限公司 2019-10-03 WO disclosed