Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18485326 | 0.98 | HPGD (0.61) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL1299276 | 0.94 | HPGD (0.65) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL1299273 | 0.94 | HPGD (0.65) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL1299272 | 0.94 | HPGD (0.65) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL18485328 | 0.92 | HPGD (0.69) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL18485319 | 0.85 | EPHX2 (0.51) | HPGDALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL1117898 | 0.83 | HPGD (0.81) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL3458439 | 0.82 | HPGD (0.61) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL2946268 | 0.81 | HPGD (0.78) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL2946264 | 0.81 | HPGD (0.78) | HPGDALDH1A1TSHRLMNACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773555-A1 | FACTOR XIIA INHIBITORS | University of Leeds (GB) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019186164-A1 | FACTOR XIIA INHIBITORS | UNIVERSITY OF LEEDS (GB) | 2019-10-03 | — | — | WO | disclosed |