Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.60 |
| ▸ | CCND1 | P24385 | 5/20 | 0.60 |
| ▸ | CCND3 | P30281 | 4/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | KLK1 | P06870 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114117 | 0.86 | CDK4 (0.78) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL10268248 | 0.85 | CDK4 (0.62) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL160571 | 0.84 | CDK4 (0.55) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL2143706 | 0.84 | CDK4 (0.60) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL2142033 | 0.84 | CDK4 (0.60) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL15602984 | 0.84 | CDK4 (0.60) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL15602945 | 0.83 | CDK4 (0.54) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL110934 | 0.82 | CDK4 (0.53) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL2142259 | 0.80 | CDK4 (0.59) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL110043 | 0.80 | CDK4 (0.60) | CDK4CCND1CCND3CDK6CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101064-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-04-26 | — | — | US | disclosed |
| US-20120101064-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101064-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | CDK3, CCNI, CDK1 | CDK4 13/4885CCND1 30/4885CCND3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.