Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 15/20 | 0.81 |
| ▸ | RET | P07949 | 5/20 | 0.71 |
| ▸ | TEK | Q02763 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | TIE1 | P35590 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | MERTK | Q12866 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28533834 | 0.95 | AXL (0.82) | AXLRETTEKAURKALCK | |
| SCHEMBL21431951 | 0.92 | AXL (0.80) | AXLRETTEKAURKALCK | |
| SCHEMBL30216601 | 0.92 | AXL (0.80) | AXLRETTEKAURKALCK | |
| SCHEMBL21408207 | 0.89 | AXL (1.00) | AXLRETTEKSTK10CSF1R | |
| SCHEMBL30216608 | 0.89 | AXL (1.00) | AXLRETTEKSTK10CSF1R | |
| SCHEMBL30216593 | 0.87 | AXL (0.79) | AXLRETTEKSTK10CSF1R | |
| SCHEMBL28521070 | 0.87 | AXL (0.79) | AXLRETTEKSTK10CSF1R | |
| SCHEMBL21432108 | 0.86 | AXL (1.00) | AXLRETTEKSTK10CSF1R | |
| SCHEMBL21432109 | 0.85 | AXL (1.00) | AXLRETTEKSTK10CSF1R | |
| SCHEMBL21408216 | 0.82 | AXL (1.00) | AXLRETTEKSTK10CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313213-B | 3-amino pyrazole compound and application thereof | 上海海和药物研究开发股份有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-112313213-A | 3-amino pyrazole compound and application thereof | 上海海和药物研究开发股份有限公司 | 2021-02-02 | — | — | CN | claimed |
| CN-112313213-B | 3-amino pyrazole compound and application thereof | 上海海和药物研究开发股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112313213-A | 3-amino pyrazole compound and application thereof | 上海海和药物研究开发股份有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019184918-A1 | 3-AMINOPYRAZOLE COMPOUND AND APPLICATION THEREOF | 暨南大学 | 2019-10-03 | — | — | WO | disclosed |