Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 6/20 | 0.51 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.51 |
| ▸ | VHL | P40337 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21405369 | 0.90 | SMARCA2 (0.50) | SMARCA2SMARCA4VHLSIGMAR1KCNH2 | |
| SCHEMBL29838301 | 0.90 | SMARCA2 (0.50) | SMARCA2SMARCA4VHLSIGMAR1KCNH2 | |
| SCHEMBL30469009 | 0.88 | SMARCA2 (0.50) | SMARCA2SMARCA4VHLDRD3 | |
| SCHEMBL25201422 | 0.88 | SMARCA2 (0.50) | SMARCA2SMARCA4VHLDRD3 | |
| SCHEMBL30469012 | 0.88 | SMARCA2 (0.50) | SMARCA2SMARCA4VHLDRD3 | |
| SCHEMBL21439162 | 0.82 | SMARCA2 (0.63) | SMARCA2SMARCA4VHLKMT2A | |
| SCHEMBL25267215 | 0.81 | SMARCA2 (0.47) | SMARCA2SMARCA4VHLDRD3 | |
| SCHEMBL29362646 | 0.81 | SMARCA2 (0.47) | SMARCA2SMARCA4VHLDRD3 | |
| SCHEMBL25206583 | 0.81 | SMARCA2 (0.47) | SMARCA2SMARCA4VHLDRD3 | |
| SCHEMBL21405286 | 0.81 | SMARCA2 (0.58) | SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774789-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019195201-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |