Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 13/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365725 | 1.00 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1366758 | 0.84 | HDAC6 (0.52) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1366117 | 0.83 | HDAC1 (0.45) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1365029 | 0.83 | HDAC6 (0.47) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302088 | 0.83 | HDAC6 (0.47) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1366934 | 0.82 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL12142364 | 0.82 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL2144014 | 0.78 | HDAC1 (0.60) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL5062540 | 0.78 | HDAC1 (0.60) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1364891 | 0.77 | KCNH2 (0.49) | HDAC3HDAC1HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343286-A1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2011-07-13 | — | — | EP | disclosed |