Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144246 | 0.89 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145018 | 0.87 | JAK2 (0.47) | JAK2JAK3PTK2KDRMET | |
| SCHEMBL2145889 | 0.86 | JAK2 (0.44) | JAK2JAK3PTK2KDRMET | |
| SCHEMBL3214565 | 0.83 | JAK2 (0.60) | JAK2JAK3PTK2 | |
| SCHEMBL2145425 | 0.81 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13486894 | 0.80 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144914 | 0.79 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144146 | 0.79 | JAK2 (0.48) | JAK2JAK3PTK2 | |
| SCHEMBL2144472 | 0.79 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144594 | 0.79 | PIK3CA (0.49) | JAK2JAK3PTK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |