Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723115 | 0.82 | EPHX1 (0.52) | EPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL27046896 | 0.82 | EPHX1 (0.52) | EPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL9000960 | 0.78 | SMN1; SMN2 (0.50) | EPHX1SMN1; SMN2EPHX2SIGMAR1NPSR1 | |
| SCHEMBL22055472 | 0.76 | SMN1; SMN2 (0.78) | EPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL931252 | 0.76 | SMN1; SMN2 (0.78) | EPHX1SMN1; SMN2EPHX2 | |
| Hydrochloric Acid SCHEMBL11875799 | 0.76 | SMN1; SMN2 (0.51) | EPHX1SMN1; SMN2EPHX2SIGMAR1NPSR1 | |
| SCHEMBL8493278 | 0.76 | SMN1; SMN2 (0.48) | EPHX1SMN1; SMN2EPHX2SIGMAR1NPSR1 | |
| SCHEMBL7888130 | 0.75 | SMN1; SMN2 (0.60) | EPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL28519865 | 0.75 | SMN1; SMN2 (0.60) | EPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL21443012 | 0.74 | SMN1; SMN2 (0.75) | EPHX1SMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3231798-B1 | THIAZOLE INTERMEDIATES USEFUL IN THE PREPARATION OF RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |