SCHEMBL21443215

SCHEMBL21443215

Cc1cc2c3c([nH]c2cc1Br)C(C)(C)c1ccc(OCC(=O)O)cc1C3=O

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL897887 0.86 ALK (1.00) ALK
SCHEMBL897865 0.78 ALK (0.85) ALK
SCHEMBL897289 0.78 ALK (0.81) ALK
SCHEMBL1755753 0.77 ALK (0.79) ALK
SCHEMBL896791 0.77 ALK (0.82) ALK
SCHEMBL20366588 0.77 ALK (0.65) ALK
SCHEMBL7808756 0.74 ALK (0.75) ALK
SCHEMBL1755987 0.74 ALK (0.66) ALK
SCHEMBL7805612 0.74 ALK (0.65) ALK
SCHEMBL7808954 0.73 ALK (0.64) ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3345903-B1 TETRACYCLIC COMPOUNDS CHUGAI PHARMACEUTICAL CO LTD (JP) 2019-10-09 EP disclosed