Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.60 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | BLK | P51451 | 1/20 | 0.48 |
| ▸ | BMX | P51813 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228637 | 0.89 | EGFR (0.78) | EGFRNUAK2NUAK1ITKJAK2 | |
| SCHEMBL29722352 | 0.89 | EGFR (0.78) | EGFRNUAK2NUAK1ITKJAK2 | |
| SCHEMBL13166469 | 0.79 | EGFR (0.80) | EGFRNUAK2NUAK1ITKBTK | |
| SCHEMBL16391084 | 0.76 | EGFR (0.69) | EGFRNUAK1ITKJAK2BLK | |
| SCHEMBL29722245 | 0.75 | EGFR (1.00) | EGFRITKJAK3BTK | |
| SCHEMBL13165553 | 0.75 | EGFR (1.00) | EGFRITKJAK3BTK | |
| SCHEMBL18165638 | 0.75 | EGFR (0.65) | EGFRITKJAK2BLKBMX | |
| SCHEMBL23450611 | 0.74 | BTK (0.71) | EGFRJAK2BLKJAK3BTK | |
| SCHEMBL16391080 | 0.74 | EGFR (0.65) | EGFRITKJAK2BLKBMX | |
| SCHEMBL31060495 | 0.72 | EGFR (1.00) | EGFRNUAK2NUAK1ITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549934-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2019-10-09 | — | — | EP | disclosed |