Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.80 |
| ▸ | ITK | Q08881 | 12/20 | 0.80 |
| ▸ | BTK | Q06187 | 5/20 | 0.76 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165644 | 0.92 | EGFR (0.77) | EGFRITKBTKJAK3 | |
| SCHEMBL14769280 | 0.90 | EGFR (0.81) | EGFRITKBTK | |
| SCHEMBL14791244 | 0.89 | EGFR (0.72) | EGFRITKBTKJAK3 | |
| SCHEMBL14769084 | 0.89 | EGFR (0.72) | EGFRITKBTKJAK3 | |
| SCHEMBL2353964 | 0.89 | EGFR (1.00) | EGFRITKBTKJAK3 | |
| SCHEMBL13166543 | 0.89 | EGFR (0.75) | EGFRITKBTKJAK3 | |
| SCHEMBL21443612 | 0.89 | ITK (0.65) | EGFRITKBTK | |
| SCHEMBL12518316 | 0.88 | EGFR (0.73) | EGFRITKBTKJAK3 | |
| SCHEMBL12518349 | 0.87 | EGFR (0.81) | EGFRITKBTK | |
| SCHEMBL2352426 | 0.87 | BTK (1.00) | EGFRITKBTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549934-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2019-10-09 | — | — | EP | disclosed |