Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.72 |
| ▸ | EGFR | P00533 | 17/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12518362 | 0.84 | ITK (1.00) | ITKEGFRJAK3BTK | |
| SCHEMBL29722385 | 0.84 | ITK (1.00) | ITKEGFRJAK3BTK | |
| SCHEMBL16266938 | 0.84 | ITK (1.00) | ITKEGFRJAK3BTK | |
| SCHEMBL21443587 | 0.84 | EGFR (0.63) | ITKEGFRJAK3BTK | |
| SCHEMBL12518438 | 0.83 | EGFR (0.88) | ITKEGFRJAK3BTK | |
| SCHEMBL29722539 | 0.83 | EGFR (0.88) | ITKEGFRJAK3BTK | |
| SCHEMBL2350864 | 0.82 | EGFR (0.82) | ITKEGFRJAK3BTK | |
| SCHEMBL12518399 | 0.82 | ITK (0.79) | ITKEGFRJAK3BTK | |
| SCHEMBL29722823 | 0.82 | ITK (0.79) | ITKEGFRJAK3BTK | |
| SCHEMBL13606336 | 0.81 | EGFR (1.00) | ITKEGFRJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549934-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2019-10-09 | — | — | EP | disclosed |