Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.60 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.60 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | IDE | P14735 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18737415 | 1.00 | TDP1 (0.60) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19069181 | 1.00 | TDP1 (0.60) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL12435801 | 1.00 | TDP1 (0.60) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19735573 | 0.92 | F2 (0.59) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL22420154 | 0.92 | F2 (0.59) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18469836 | 0.92 | F2 (0.59) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19176655 | 0.92 | F2 (0.59) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18897254 | 0.91 | TDP1 (0.59) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18897255 | 0.91 | F2 (0.57) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19735730 | 0.91 | F2 (0.59) | TDP1F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549934-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2019-10-09 | — | — | EP | disclosed |