Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.40 |
| ▸ | JAK1 | P23458 | 9/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 7/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144254 | 0.92 | JAK2 (0.41) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL3304644 | 0.89 | JAK2 (0.43) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL2144919 | 0.89 | JAK2 (0.43) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL3297815 | 0.89 | JAK2 (0.43) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL2144106 | 0.83 | JAK2 (0.42) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL2144789 | 0.82 | JAK2 (0.39) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL3303623 | 0.82 | JAK2 (0.38) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL3304865 | 0.82 | SYK (0.37) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL2144531 | 0.82 | JAK2 (0.40) | JAK2JAK1TBK1JAK3PTK2 | |
| SCHEMBL3303893 | 0.82 | JAK2 (0.40) | JAK2JAK1TBK1JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |