Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.49 |
| ▸ | JAK3 | P52333 | 17/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 16/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145124 | 0.81 | SYK (0.55) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144495 | 0.74 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3305387 | 0.73 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13504378 | 0.72 | JAK2 (0.51) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145239 | 0.72 | JAK2 (0.49) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144480 | 0.72 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144170 | 0.72 | JAK2 (0.48) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144842 | 0.71 | JAK2 (0.48) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13391135 | 0.70 | JAK2 (0.51) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3303044 | 0.70 | JAK2 (0.77) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |