Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20654282 | 1.00 | ATM (0.50) | ATMALDH1A1KDM4EEPHX2TLR4 | |
| SCHEMBL22996466 | 1.00 | ATM (0.50) | ATMALDH1A1KDM4EEPHX2TLR4 | |
| SCHEMBL20688150 | 0.85 | ATM (0.46) | ATMALDH1A1KDM4EEPHX2TLR4 | |
| SCHEMBL29318657 | 0.85 | ATM (0.46) | ATMALDH1A1KDM4EEPHX2TLR4 | |
| SCHEMBL20242212 | 0.82 | EPHX2 (0.38) | ATMALDH1A1KDM4EEPHX2 | |
| SCHEMBL22996544 | 0.82 | EPHX2 (0.38) | ATMALDH1A1KDM4EEPHX2 | |
| SCHEMBL21452884 | 0.80 | ATM (0.48) | ATMALDH1A1KDM4ETLR4MTNR1A | |
| SCHEMBL29823402 | 0.80 | EPHX2 (0.37) | ATMEPHX2 | |
| SCHEMBL21452886 | 0.80 | ATM (0.48) | ATMALDH1A1KDM4ETLR4MTNR1A | |
| SCHEMBL12409405 | 0.80 | EPHX2 (0.51) | ATMALDH1A1KDM4EEPHX2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793565-B1 | MCL-1 INHIBITORS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |