Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.42 |
| ▸ | BCR | P11274 | 5/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21433971 | 0.85 | SCN9A (0.49) | ABL1BCRTRPA1SCN9AMMP12 | |
| SCHEMBL21433963 | 0.83 | ABL1 (0.46) | ABL1BCRTRPA1SCN9AITGB2 | |
| SCHEMBL21453035 | 0.78 | ABL1 (0.42) | ABL1BCRDPP4 | |
| SCHEMBL21433972 | 0.78 | ITGB2 (0.54) | ABL1BCRTRPA1SCN9AITGB2 | |
| SCHEMBL21434172 | 0.77 | NPC1 (0.62) | ABL1BCRSCN9AFAAHDPP4 | |
| SCHEMBL21434055 | 0.77 | EPHX2 (0.44) | ABL1BCRTRPA1SCN9AITGB2 | |
| SCHEMBL21434098 | 0.77 | SMPD3 (0.51) | ABL1BCRTRPA1SCN9AITGB2 | |
| SCHEMBL21433969 | 0.76 | CHRM4 (0.51) | ABL1BCRTRPA1CHRM4 | |
| SCHEMBL21434043 | 0.76 | MAP4K4 (0.46) | ABL1BCRTRPA1SCN9AITGB2 | |
| SCHEMBL21434152 | 0.75 | NOTUM (0.55) | ABL1BCRSCN9AMMP12ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |