Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21433958 | 0.85 | SCN9A (0.48) | MCHR1SCN9ARAB9ASMN1; SMN2ABL1 | |
| SCHEMBL21434128 | 0.82 | SCN9A (0.48) | MCHR1SCN9ARAB9ASMN1; SMN2ABL1 | |
| SCHEMBL21433983 | 0.81 | SMN1; SMN2 (0.51) | MCHR1SCN9ARAB9ASMN1; SMN2ABL1 | |
| SCHEMBL21433915 | 0.80 | SCN9A (0.46) | MCHR1SCN9ARAB9ASMN1; SMN2ABL1 | |
| SCHEMBL21433972 | 0.77 | ITGB2 (0.54) | MCHR1SCN9ARAB9ASMN1; SMN2ABL1 | |
| SCHEMBL21452844 | 0.72 | ITGB2 (0.44) | SCN9ARAB9ASMN1; SMN2ABL1ITGB2 | |
| SCHEMBL21434071 | 0.72 | TDP1 (0.46) | MCHR1SCN9ARAB9ASMN1; SMN2ABL1 | |
| SCHEMBL2558990 | 0.71 | SMN1; SMN2 (0.75) | RAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL31381264 | 0.71 | ABL1 (0.67) | MCHR1RAB9ASMN1; SMN2ABL1KDM4E | |
| SCHEMBL21434136 | 0.70 | CHRM3 (0.53) | MCHR1PDE4APDE4BPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |