Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.50 |
| ▸ | JAK3 | P52333 | 6/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3306813 | 0.85 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144427 | 0.79 | JAK2 (0.46) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145654 | 0.79 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144971 | 0.78 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144348 | 0.78 | JAK2 (0.50) | JAK2JAK3PTK2JAK1NUDT1 | |
| SCHEMBL2144146 | 0.76 | JAK2 (0.48) | JAK2JAK3PTK2 | |
| SCHEMBL2144307 | 0.76 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144480 | 0.76 | JAK2 (0.64) | JAK2JAK3PTK2JAK1NUDT1 | |
| SCHEMBL2145786 | 0.74 | JAK2 (0.55) | JAK2JAK3PTK2JAK1NUDT1 | |
| SCHEMBL13390972 | 0.74 | JAK2 (0.49) | JAK2JAK3PTK2JAK1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |