Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21452934 | 0.87 | KMT2A (0.42) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21434101 | 0.85 | KMT2A (0.61) | KMT2AGALR2KDM4EALDH1A1HPGD | |
| SCHEMBL21452862 | 0.80 | KMT2A (0.44) | KMT2AMAP3K12CHRM3PDE4APDE4B | |
| SCHEMBL21433981 | 0.78 | SMPD3 (0.47) | ABL1ADORA3 | |
| SCHEMBL21433979 | 0.78 | SMPD3 (0.47) | ABL1ADORA3 | |
| SCHEMBL21452494 | 0.78 | SMPD3 (0.47) | ABL1ADORA3 | |
| SCHEMBL21434128 | 0.77 | SCN9A (0.48) | KMT2AKDM4EABL1ADORA3PDE4A | |
| SCHEMBL21434136 | 0.76 | CHRM3 (0.53) | KMT2AUSP30GALR2KDM4EALDH1A1 | |
| SCHEMBL21434029 | 0.76 | SMPD3 (0.55) | KMT2AABL1ADORA3 | |
| SCHEMBL21433975 | 0.75 | KMT2A (0.41) | KMT2AGABBR2GABBR1GALR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |