SCHEMBL21453640

SCHEMBL21453640

c1ccc(-c2ccc(-n3c4ccccc4c4c3ccc3c5cccc6c7cccc8sc9cccc(c%10ccccc%10n(c65)c34)c9c87)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HDAC4 P56524 1/20 0.34
HSD17B10 Q99714 1/20 0.30
PDE1B Q01064 1/20 0.30
PDE3A Q14432 1/20 0.30
PDE11A Q9HCR9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21454457 0.96 KDM4E (0.36) KDM4EATML3MBTL1HDAC4
SCHEMBL21453635 0.94 KDM4E (0.34) KDM4EATML3MBTL1HDAC4
SCHEMBL21454120 0.93 ATM (0.45) KDM4EATML3MBTL1HSD17B10PDE1B
SCHEMBL21453643 0.91 KDM4E (0.38) KDM4EATML3MBTL1HDAC4HSD17B10
SCHEMBL21453648 0.90 KDM4E (0.37) KDM4EATML3MBTL1HDAC4HSD17B10
SCHEMBL21454100 0.89 KDM4E (0.45) KDM4EATML3MBTL1HDAC4
SCHEMBL21454126 0.89 KDM4E (0.35) KDM4EATML3MBTL1HDAC4HSD17B10
SCHEMBL21453801 0.88 ATM (0.43) KDM4EATML3MBTL1HSD17B10PDE1B
SCHEMBL19890592 0.88 KDM4E (0.46) KDM4EATML3MBTL1HDAC4
SCHEMBL21453823 0.87 KDM4E (0.39) KDM4EATML3MBTL1HDAC4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885ATM 3337/4885L3MBTL1 3731/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885ATM 3337/4885L3MBTL1 3731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.