SCHEMBL21454130

SCHEMBL21454130

c1ccc(-c2nc(-c3ccccc3)nc(-n3c4ccccc4c4ccc5c6cccc7c8cccc9sc%10cccc(c%11ccccc%11n(c76)c5c43)c%10c98)n2)cc1

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.32
HSD17B10 Q99714 2/20 0.32
TSHR P16473 1/20 0.32
NPC1 O15118 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
HPGD P15428 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PDE1B Q01064 1/20 0.30
PDE3A Q14432 1/20 0.30
PDE11A Q9HCR9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21454227 0.96 KDM4E (0.30) KDM4EHSD17B10NPC1LMNATP53
SCHEMBL21453670 0.95 KDM4E (0.31) KDM4EHSD17B10TSHR
SCHEMBL21454124 0.90 KDM4E (0.31) KDM4EHSD17B10TSHR
SCHEMBL21453658 0.90 KDM4E (0.31) KDM4EHSD17B10TSHR
SCHEMBL21453660 0.89 KDM4E (0.30) KDM4EHSD17B10TSHR
SCHEMBL23474697 0.89 KDM4E (0.36) KDM4EHSD17B10TSHRHPGD
SCHEMBL21454098 0.88 KDM4E (0.35) KDM4EHSD17B10TSHRHPGD
SCHEMBL21454248 0.87
SCHEMBL21454084 0.87 HPGD (0.41) KDM4EHSD17B10NPC1LMNATP53
SCHEMBL25479770 0.87 MEN1 (0.35) KDM4EHSD17B10TSHRLMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885HSD17B10 1511/4885TSHR 4332/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885HSD17B10 1511/4885TSHR 4332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.