Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 12/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25855982 | 0.87 | STING1 (0.54) | STING1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL21437154 | 0.87 | STING1 (0.68) | STING1ALDH1A1HPGDHDAC6L3MBTL1 | |
| SCHEMBL24175695 | 0.86 | STING1 (0.53) | STING1KDM4E | |
| SCHEMBL21406148 | 0.83 | STING1 (0.52) | STING1ALDH1A1KDM4EHDAC6L3MBTL1 | |
| SCHEMBL21454711 | 0.81 | STING1 (0.52) | STING1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21405827 | 0.80 | STING1 (0.45) | STING1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30501004 | 0.80 | STING1 (0.69) | STING1 | |
| SCHEMBL21437118 | 0.80 | STING1 (0.69) | STING1 | |
| SCHEMBL30501006 | 0.80 | STING1 (0.69) | STING1 | |
| SCHEMBL25855984 | 0.80 | STING1 (0.57) | STING1NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195063-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | WO | disclosed |