Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095412 | 0.83 | RPS6KA1 (0.47) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL30352481 | 0.83 | PRMT5 (0.47) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL20095409 | 0.83 | PRMT5 (0.47) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL27297404 | 0.82 | PRMT5 (0.49) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL22664611 | 0.82 | PRMT5 (0.45) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL17664633 | 0.82 | PRMT5 (0.45) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL22664605 | 0.82 | PRMT5 (0.45) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL25574986 | 0.82 | PRMT5 (0.46) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL24502715 | 0.81 | PRMT5 (0.48) | PRMT5WDR77RPS6KA1AAK1KDM4A | |
| SCHEMBL29903067 | 0.81 | PRMT5 (0.48) | PRMT5WDR77RPS6KA1AAK1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939658-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |