Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146006 | 1.00 | HPGD (0.47) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL29014961 | 0.89 | RECQL (0.49) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL22468372 | 0.88 | HPGD (0.44) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL28580478 | 0.88 | HPGD (0.44) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL56449 | 0.85 | HPGD (0.51) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL55991 | 0.84 | HPGD (0.47) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL31320024 | 0.84 | RECQL (0.48) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL29718457 | 0.84 | HPGD (0.47) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL57472 | 0.84 | HPGD (0.47) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL16362675 | 0.83 | HPGD (0.46) | HPGDMAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |