Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | PPP5C | P53041 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28233898 | 0.88 | GBA2 (0.40) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL10084439 | 0.83 | ATM (0.53) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL10292032 | 0.83 | ATM (0.53) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL20558080 | 0.83 | ATM (0.53) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL1585134 | 0.83 | GBA2 (0.46) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL31728231 | 0.83 | ATM (0.53) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL3663153 | 0.83 | ATM (0.53) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL10084437 | 0.83 | ATM (0.53) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL26118872 | 0.82 | TMEM97 (0.38) | GBA2LMNAPOLBSMN1; SMN2ECE1 | |
| SCHEMBL44642 | 0.82 | GBA2 (0.42) | GBA2LMNAPOLBSMN1; SMN2ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |