Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 20/20 | 0.74 |
| ▸ | AURKC | Q9UQB9 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198808 | 1.00 | AURKA (0.74) | AURKAAURKBAURKC | |
| SCHEMBL2177582 | 0.91 | AURKA (0.62) | AURKAAURKBAURKC | |
| SCHEMBL2148583 | 0.91 | AURKA (0.62) | AURKAAURKBAURKC | |
| SCHEMBL2148674 | 0.89 | AURKA (0.61) | AURKAAURKBAURKC | |
| SCHEMBL2145969 | 0.88 | AURKA (0.71) | AURKAAURKBAURKC | |
| SCHEMBL2214620 | 0.88 | AURKA (0.71) | AURKAAURKBAURKC | |
| SCHEMBL2165141 | 0.87 | AURKA (0.71) | AURKAAURKBAURKC | |
| SCHEMBL2146343 | 0.87 | AURKA (0.58) | AURKAAURKBAURKC | |
| SCHEMBL2149167 | 0.86 | AURKA (0.60) | AURKAAURKBAURKC | |
| SCHEMBL2148608 | 0.84 | AURKA (0.73) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | claimed |